Divergence of Transcription Factor Binding Sites Across Related Yeast Species

Anthony R. Borneman,^1*Tara A. Gianoulis,² Zhengdong D. Zhang,³ Haiyuan Yu,³ Joel Rozowsky,³ Michael R. Seringhaus,³ Lu Yong Wang,⁴ Mark Gerstein,^2,3,5Michael Snyder

In yeast, gene regulatory elements evolve much more rapidly than the genes they control and so may be responsible for much of the diversity among species.