Innovations in DNA sequencing and genotyping are opening doors for personal genomics. Nathan Blow explores these technological advances and their implications.
The era of personal genomics is upon us, with advances in technologies such as DNA sequencing and genotyping fuelling the fires. Personal genomics is a story of researchers looking for genetic clues to our most common diseases, of dazzling advances in genetic analysis technology and of lingering questions about how the public will view and use the information.
DNA sequencing is clearly driving much of this revolution in personal genomics. In late May 2007, 454 Life Sciences in Branford, Connecticut, and the Human Genome Sequencing Center at the Baylor College of Medicine in Houston, Texas, made headlines around the world with the announcement that they had sequenced James Watson's entire genome using 454 Life Sciences' next-generation sequencing technology. And just four months later researchers at the J. Craig Venter Institute in Rockville, Maryland, along with collaborators at The Hospital for Sick Children in Toronto, Canada, and the University of California, San Diego, published the first full genome sequence of a single individual — Craig Venter1. This analysis, though, relied on the traditional approach of Sanger sequencing.
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