Patrick J. Keeling*A genome sequence might provide answers to major questions about the biology and evolutionary history of an organism. Alternatively, it might reveal more problems than solutions, and its true value then lies in identifying what questions to ask. Perhaps the most interesting genomes do both: They are a panacea and a Pandora's box. On page 1921 in this issue, Morrison et al. (1) describe such a genome from the diplomonad protist Giardia lamblia, a human intestinal parasite. The compact Giardia genome is replete with information ranging from the simplicity of its molecular systems to how the parasite interacts with its environment. However, the evolutionary history of Giardia is not so clearly written in the genome, reigniting a smoldering debate about the origin of Giardia and its relationship to other eukaryotes.
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